Temporal pattern of gene expression and histology of stress fracture healing

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Temporal pattern of gene expression and histology of stress fracture healing.

Loading of the rat ulna is an ideal model to examine stress fracture healing. The aim of this study was to undertake a detailed examination of the histology, histomorphometry and gene expression of the healing and remodelling process initiated by fatigue loading of the rat ulna. Ulnae were harvested 1, 2, 4, 6, 8, and 10 weeks following creation of a stress fracture. Stress fracture healing inv...

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Bones have a large intrinsic capacity for repair and regeneration following an injury, however, an estimated 5-10% of nearly 8 million fractures that occur every year in the United States lead to nonunions. The process of bone regeneration is a complex trait that brings together different complements of molecular and cellular interactions to carry out its necessary mechanical functions. These i...

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Spatial and Temporal Expression of Periostin, a Novel Gene Detected by Complementarydna Microarray during Fracture Healing

Introduction Recent advances in molecular biological techniques have enabled investigators to determine the spatial and temporal expression of genes during fracture healing. Thus far, however, a limited number of genes have been identified, and details of the healing processes have not been fully established. In the previous study, we have used a quantitative cDNA microarray technique, and comp...

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ژورنال

عنوان ژورنال: Bone

سال: 2010

ISSN: 8756-3282

DOI: 10.1016/j.bone.2009.10.009